Genomic basis of copepod local adaptation to harmful algaeNo significant difference in genetic compositionMany genes of small effectSmall number of genes of moderate effectRegulatory mechanismsToo much noisecomplex trait refined over many generationsSimple gene/allele driving difference, minimal pleiotropyDifference in genes associated with saxitoxin tolerance in other organismsUnique mechanism of toleranceIon channelsMetabolismNeutralization proteins